Mitochondria are tiny organelles within each of our cells. Their job is critical: they provide the energy cells need to function. When mitochondria function poorly, our bodies may experience a variety of problems ranging from neurological issues to muscle cramps. According to a new study, mitochondrial dysfunction is more common among people with autism. The study, which looked at a total of ten children (10 with and 10 without an autism spectrum diagnosis), found a signficant decrease in mitochondrial function among children with autism. Researchers were able to test mitochondrial function through a blood test; this in itself was significant because typically mitochondrial disorders can only be identified through an expensive and painful muscle biopsy.
While the study does not specifically suggest that mitochondrial issues are a contributing cause of autism, the press release does state: "Taken together, the various abnormalities, defects and levels of malfunction measured in the mitochondria of autistic children imply that oxidative stress in these organelles could be influencing autism's onset." The press release goes on to quote one of the researchers:
Giulivi cautions that these findings do not amount to establishing a cause for autism.
"We took a snapshot of the mitochondrial dysfunction when the children were 2-to-5 years old. Whether this happened before they were born or after, this study can't tell us," she said. "However, the research furthers the understanding of autism on several fronts and may, if replicated, be used to help physicians diagnose the problem earlier."
"Pediatricians need to be aware of this issue so that they can ask the right questions to determine whether children with autism have vision or hearing problems or myopathies," Giulivi said. Exercise intolerance in the form of muscle cramps during intensive physical activity is one of the characteristics of mitochondrial myopathies.
The chemical fingerprints of mitochondrial dysfunction also may hold potential as a diagnostic tool. Giulivi and colleagues are now examining the mitochondrial DNA of their subjects more closely to pinpoint more precise differences between autistic and non-autistic children.
This study is of interest to the autism community not only because of its scientific relevance, but also because it seems to relate directly to the Vaccine Court case in which the Poling family won a multi-million dollar settlement. The Poling's were compensated for their daughter's vaccine-related injuries which, according to medical evidence, were the result of an underlying, asymptomatic mitochondrial disorder. While there is some uncertainty as to whether Hannah is "officially" diagnosable on the autism spectrum, there is no doubt that her symptoms are at the very least very similar to the symptoms of autism.
More About Mitochondrial Disorders, Autism and the Poling Case
- Poling Family to Receive $1.5 Million from Vaccine Court
- Vaccines, Mitochondrial Disease and Autism
- Mitochondrial Disease and Autism
- Autism and the Vaccine Court
New Study Links Mitochondrial Issues and Autism originally appeared on About.com Autism on Tuesday, November 30th, 2010 at 16:21:10.
